Department of CHEMISTRY

GITAM School of Science, Hyderabad campus

Rambabu G


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Contact
rgundla@gitam.edu
Education

Ph. D.

Research Areas
  • Medicinal Chemistry
  • Computational Chemistry
  • Material Science
  • Analytical Chemistry

Publications 54

Synthesis of New Chiral (R)BINOL Derivatives under Microwave Irradiation andEvaluation of their Antibacterial and Glucosidase Inhibitory Activity.

Chemistry select, Google scholar, 2019, accepted, 00


Rational design, molecular docking and synthesis of novel homopiperazinelinked imidazo[1,2a]pyrimidine derivatives as potent cytotoxic andantimicrobial agents.

Bioorganic & Medicinal Chemistry Letters, Scopus, 2019, 0, 00


Synthesis, Characterization and Antibacterial Activity of Some NovelC7Substituted2morpholinoN(pyridin2ylmethyl)quinazolin4amine Derivatives.

Der Pharma Chemica, , Others, 2018, 10, 40-48


Design, Synthesis and Biological Evaluation of 2(((5aryl1,2,4oxadiazol3yl)methyl)thio)benzo[d]oxazolesNew Antiinflammatory and Antioxidant Agents.

Chemistry select, Scopus, 2018, 3, 1-7


Focused library design and synthesis of 2mercapto benzothiazolelinked 1,2,4oxadiazoles as COX25LOX inhibitors.

Journal of Molecular Structure , Scopus, 2018, 1159, 193-204


Synthesis and biological potentials of some new 1,3,4oxadiazoleanalogues.

Medicinal chemistry research , Scopus, 2018, 27, 864-883


Stabilityindicating method ofentacaponerelated substances usingUPLC in finished dosage form.

CURRENT SCIENCE, Scopus, 2018, 114, 644


Synthesis, Biological Evaluation and Docking Studies of 1,3,4OxadiazoleFused Benzothiazole Derivatives for Anticancer Drugs.

Letters in Drug Design & Discovery, Scopus, 2018, 15, 199-1307


An approach towards the oxidation of 2amino4Hchromenes to 2imino2Hchromenes.

Tetrahedron Letters , Scopus, 2018, 59, 4616-4619


Molecular hybrid design, synthesis and biological evaluation of Nphenyl sulfonamide linked Nacyl hydrazone derivatives functioning as COX2 inhibitors new antiinflammatory, antioxidant and antibacterial agents.

NEW JOURNAL OF CHEMISTRY, Scopus, 2017, 41, 13516-13532


New AntiInflammatory Hybrid NAcyl HydrazoneLinked Isoxazole Derivatives as COX2 InhibitorsRational Design, Synthesis and Biological Evaluation .

Chemistry selective, Scopus, 2017, 2, 8091-8100


A diversity oriented synthesis of natural product inspired molecular libraries.

Organic & Biomolecular Chemistry, Scopus, 2017, 15, 9108-9120


Synthesis, molecular docking and in vitroantiproliferative activity of novel pyrano[3,2c]carbazole derivatives.

New J. Chem.,, Scopus, 2016, 40, 8305--8315


DESIGNING NOVEL MEK1 INHIBITORS AS ANTICANCER AGENTS.

IJLP, Google scholar, 2016, 6, 22-33


Ionic liquidwater mixture promoted organictransformations.

RSC Adv., , 5, , Scopus, 2015, 5, 51035-51054


Design, synthesis, and biological evaluation of quinazolinederivatives as aglucosidase inhibitors.

Medicinal chemistry research , Scopus, 2015, 24, 2227-2237


Boronic acidcontaining CXCR12 antagonists optimization ofmetabolic stability, in vivo evaluation, and a proposed receptorbinding model.

BMCL, Web of science, 2015, 25, 2280-2284


Design, synthesis and screening studies of potent thiazol2amine derivatives as fibroblast growth factor receptor 1 inhibitors. .

Current Topics in Medicinal Chemistry, Web of science, 2014, 14, 2031-2041


Pyrrolidine and piperidine based chiral spiro andfused scaffolds via buildcouplepair approach. .

RSC Adv, Scopus, 2014, 14, 10619-10626


A reagent based DOS strategy via Evans chiral auxiliaryhighly stereoselective Michael reaction towardsoptically active quinolizidinones, piperidinones andpyrrolidinones3.

RSC Adv., Scopus, 2013, 3, 2404-2411


Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by DtzBenzannulation.

Asian J. Org. Chem, Web of science, 2013, 2, 862-868


Synthesis of Privileged Scaffolds by Using DiversityOriented Synthesis.

Chem. Asian J. 2013, 00, 0 0, Web of science, 2013, 0, 00


Fibroblast Growth Factor Receptor Inhibitors.

Current Pharmaceutical Design, Web of science, 2013, 19, 687-701


Development of glucosidase inhibitors by roomtemperature CC cross couplings of quinazolinones.

Org. Biomol. Chem, Scopus, 2013, 11, 4778-4791


ReagentBased DOS Developing a Diastereoselective Methodology toAccess Spirocyclic and Fused Heterocyclic Ring Systems**.

Chem. Asian J., Web of science, 2012, 7, 2351-2360


Molecular modeling of Bt Cry1Ac (DIDII)ASAL (Allium sativum lectin)fusionprotein and its interaction with aminopeptidase N (APN) receptor ofManduca sexta.

Journal of Molecular Graphics and Modelling , Scopus, 2012, 33, 61-67


Discovery and Preclinical Evaluation of a Novel Class of Cytotoxic Propynoic Acid Carbamoyl Methyl Amides (PACMAs).

J. Med. Chem., Scopus, 2011, 54, 2902-2914


Virtual screening studies on HIV1 reverse transcriptase inhibitorsto design potent leads.

European Journal of Medicinal Chemistry, Scopus, 2011, 46, 851-859


A wideranging review on Nasicon type materials.

J Mater Sci, Scopus, 2011, 46, 2821-2837


A threedimensional pharmacophoremodelling of ITK inhibitors and virtualscreening for novel inhibitors.

SAR and QSAR in Environmental Research, Scopus, 2011, 22, 171-190


Ligandbased and structurebased approaches in identifyingideal pharmacophore against cJun Nterminal kinase3.

J Mol Model, Scopus, 2011, 17, 151-163


Insilico studies on anthrax lethal factor inhibitors Pharmacophore modeling andvirtual screening approaches towards designing of novel inhibitors for a killer.

Journal of Molecular Graphics and Modelling , Scopus, 2010, 29 , 256-265


Three Dimensional Molecular Field Analysis of Thiomorpholine Analogs of TACE Inhibitors Using Receptor Based Alignment.

Letters in Drug Design & Discovery, Web of science, 2010, 7 , 269-274


Combined pharmacophore and structureguided studies to identify diverseHSP90 inhibitors.

Journal of Molecular Graphics and Modelling, Scopus, 2010, 28, 472-477


Modeling of human caspase5 protein and docking studies of caspase5 inhibitors against modeled caspase5.

Journal of Global Pharma Technology , Google scholar, 2010, 2, 1-5


Discovery of potential ZAP70 kinase inhibitors Pharmacophore design,database screening and docking studies.

European Journal of Medicinal Chemistry, Scopus, 2009, 44, 4793-4800


Knowledge basedidentification of MAOB selective inhibitors using pharmacophore and structure based virtual screening models.

European Journal of Medicinal Chemistry, Scopus, 2009, 44, 3584-3590


Discovery of Novel SmallMolecule Inhibitors of Human Epidermal Growth Factor Receptor2Combined Ligand and TargetBased Approach.

J. Med. Chem. , Scopus, 2008, 51, 3367-3377


Discovery of 3acetyl4hydroxy2pyranone derivatives and theirdifluoridoborate complexes as a novel class of HIV1 integrase Inhibitors.

Bioorganic & Medicinal Chemistry, Scopus, 2008, 16, 8988-8998


QSAR analysis of 1,3diaryl4,5,6,7tetrahydro2Hisoindolederivatives as selective COX2 inhibitors.

European Journal of Medicinal Chemistry , Scopus, 2008, 43, 1559-1569


Powder Xray diffraction, infrared and conductivity studiesof AgSbMP3O12 (M Al, Ga, Fe and Cr).

Materials Research Bulletin , Scopus, 2008, 43, 1509-1518


Pharmacophore modeling and virtual screening studies to designsome potential histone deacetylase inhibitors as new leads.

Journal of Molecular Graphics and Modelling , Scopus, 2008, 26, 935-946


HIV1 Integrase Inhibitors2005^2006 Update.

Medicinal Research Reviews, Scopus, 2008, 28, 118-154


Preparation, characterization and conductivity studiesof a Nasicon system Ag32xTaxAl2x (PO4)3.(a) 204, No. .

phys. stat. sol. , Web of science, 2007, 10, 3454-3462


Preparation, characterization, conductivity and thermalexpansion studies of Ca0.5SbMP3O12 (M Al, Fe, Cr).

J Mater Sci, Web of science, 2007, 42, 3613-3620


Pharmacophore mapping of diverse classesof farnesyltransferase inhibitors. .

Bioorganic & Medicinal Chemistry Letters, Scopus, 2007, 17, 1594-1600


Preparation, characterization, and impedance studies of Li Sb M ( P O 4 ) 3 ( M Al , Fe,and Cr) .

JOURNAL OF APPLIED PHYSICS, Web of science, 2006, 100, 083707


Ligand Coordinate Analysis of SC558 from the Active Site to the Surface of COX2 AMolecular Dynamics Study. .

J. Chem. Inf. Model., Scopus, 2006, 46, 1784-1794


Synthesis, molecular docking, antiproliferative, and antimicrobialactivity of novel pyrano[3,2c]carbazole derivatives.

Med Chem Res, Scopus, 2006, 25, 2093-2103


A REVIEW ON ANTIHCV AGENTS TARGETING ACTIVE SITE AND ALLOSTERIC SITES OF NONSTRUCTURALPROTEIN 5B [NS5B].

International Journal of Pharmacy and Pharmaceutical Sciences, Google scholar, 2006, 8, 1-18


Preparation, characterization and impedance study of AgTaMP3O12(MAl, Ga, In, Cr, Fe and Y).

Solid State Ionics, Web of science, 2005, 176, 2701-2710


Virtual Screening of 4Anilinoquinazoline Analogues as EGFR Kinase InhibitorsImportance of Hydrogen Bonds in the Evaluation of Poses and Scoring Functions.

J. Chem. Inf. Model, Web of science, 2005, 45, 725-738


Design of EGFR Kinase Inhibitors A LigandBased Approachand Its Confirmation with StructureBased Studies.

Bioorganic & Medicinal Chemistry , Scopus, 2003, 11, 4643-4653


Analogue Based Design of MMP13 (Collagenase3) Inhibitors. .

Bioorganic & Medicinal Chemistry Letters, Scopus, 2002, 12, 2689-2693


Research projects 2

Title of the project NHeterocyclic CarbeneStabilized Silaallenes, Silacumulenes, Phosphaallenes and Phosphacumulenes.
Funded by DST
Duration 36 months
Sanctioned date 26 October, 2017
Title of the project Traditional and New Approaches Towards the Discovery of Dengue Protease Inhibitors Potent and Druglike Antiviral Agents against Dengue Fever
Funded by SERB_DST
Duration 36 months
Sanctioned date 04 June, 2016

Books published 1

Title of the book ComputerAided Techniques in Design of HIV1 Integrase Inhibitors
Book / Chapter Chapters
Name of the publisher Wiley Series
Subject area Medicinal Chemistry
Edition 10
Page numbers 389-413
ISBN 9780470184745
Published year 2011

Training & workshops 0

Consultancy projects 0

Patents 3

Title Pesticidal Compositions And Processes Related Thereto
Application number US 9,615,576 B2
Category US
Submitted date17 February, 2017
Title Pesticidal Compositions And Processes Related Thereto
Application number US 20140206537A1
Category US
Submitted date25 March, 2014
Title Pesticidal Compositions And Processes Related Thereto
Application number US 9,615,576 B2
Category US
Submitted date21 June, 2012

Papers in seminars & conferences 14

Seminar name Future India innovations in pharmaceutical Sciences
Organized by Nalanda college of pharmacy, Nalgonda
More info...
Seminar name Materials in Healthcare
Organized by GITAM, Hyederabd
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Seminar name Big Data Applications in Drug Repurposing (BDADR 17)
Organized by GITAM
More info...
Seminar name CRSI National symposium in chemistry
Organized by hyderabad
More info...
Seminar name Innovations and developments in Emerging research in chemical sciences
Organized by Tara Govt. College ,Sangareddy
More info...
Seminar name Modern Trends in Drug Discovery and Development (MTDDD 16
Organized by GITAM
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Seminar name Advanced Techniques in Chemical Research
Organized by SKSD mahila college, Tanuku
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Seminar name Old and Recent Trends in Chemical Science
Organized by Tara Govt. College ,Sangareddy
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Seminar name international conference on molecular spectroscopy
Organized by MGU, KOTTAYAM, KERALA
More info...
Seminar name international conference on drug design
Organized by jnu
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Seminar name centre for chemical sciences and technology
Organized by jntuh
More info...
Seminar name Recent Advances in computational Drug Design
Organized by Schrodinger
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Seminar name Biotechnology in Pharma and Food Industries
Organized by GITAM
More info...
Seminar name World congress on biotechnology
Organized by OMICS
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Research guidance 10

Title of the thesis DEVELOPMENT AND VALIDATION OF NOVEL STABILITY INDICATING METHODS FOR SELECTED DRUGS OF CANCER AND PARKINSON DISEASES USING RPHPLC AND UPLC TECHNIQUES
Name of the student Naresh Konduru
Name of the college / university GITAM
Major subject area Analytical Chemistry
Year of admission 2018
Type of admission Part time
Thesis specification PhD
Title of the thesis Rational Design, Synthesis of hetero cyclic compouds of anti cancer agents
Name of the student Madhu Sudhana Reddy Gangireddy
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Novel Design, Synthesis of hetero cyclic compouds of anti cancer agents
Name of the student Manohar Mantipally
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Design, Synthesis of hetero cyclic compouds of anti viral agents
Name of the student Venkatnarayana chowdary Maddipati
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Design, Synthesis of hetero cyclic compouds of anti cancer agents
Name of the student Gopal Muddasani
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Novel Design, Synthesis of hetero cyclic compouds of anti cancer agents
Name of the student Kalisavali
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Design, Synthesis of hetero cyclic compouds of anti viral agents
Name of the student Sidvilas
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Design, Synthesis of hetero cyclic compouds of anti cancer agents
Name of the student Anil Kumar
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2015
Type of admission Part time
Thesis specification PhD
Title of the thesis Design, synthesis and insilco studies of BenzothiazoleBenzooxazole based hetrero cyclic agents as a COX2 inhibitors
Name of the student Satyanarayan.Y
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2014
Type of admission Part time
Thesis specification PhD
Title of the thesis Identification, synthesis and biological evaluation of new Quinazoline and BINOL based Antidiabetic and Antibacterial agents
Name of the student Ashok Reddy.A
Name of the college / university GITAM
Major subject area Medicinal Chemistry
Year of admission 2014
Type of admission Part time
Thesis specification PhD

Membership in professional bodies 1

Organization name Indian Science Congress Association
Membership category Life
Membership type Member

Awards & Recognizations 2

Name of the award Best Researcher
Awarded by GITAM
Awarded year 2017
Name of the award Best Employee
Awarded by GVKBIO
Awarded year 2012

Guest lectures 0

Board member 2

Board name Wiley
Journal name Chemistry Select
Board name Elsevier
Journal name Journal Molecular Structure

Policy Making 0